Physical dependence is manifested by withdrawal symptoms after abrupt discontinuation of a drug or upon administration of an antagonist. Physical dependence and/or tolerance are not unusual during chronic opioid therapy. Addiction and misuse warning: Methadone comes with a risk of addiction even

Prescribers should always follow appropriate pain management principles of careful assessment and ongoing monitoring. The initial methadone dose should Beryllium carefully titrated to the individual. Too rapid titration for the patient's sensitivity is more likely to produce adverse effects.